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Differences in the phosphoprotein profiles of the signaling pathway in keloid fibroblasts were detected, and the expression of p53-pS15 and FOXO4 was examined in fibroblasts and keloid tissues

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Current clinical guidelines for hyperuricemia and gout emphasize a dual approach: (1) acute flare management using nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, or corticosteroids and (2) long-term urate-lowering therapy (ULT) with xanthine oxidase inhibitors (e.g., allopurinol and febuxostat) or uricosurics (e.g., probenecid) (Sattui and Gaffo, 2016)

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